منابع مشابه
Differential effects of heart rate reduction and beta-blockade on left ventricular relaxation during exercise.
Left ventricular (LV) relaxation is crucial for LV function, especially during exercise. We compared the effects of increasing doses of ivabradine, a selective inward hyperpolarization-activated current inhibitor, and atenolol on the rate and extent of LV relaxation (best fit method: time constant tau(BF), pressure asymptote P(BF)) at rest and during exercise. Eight dogs were chronically instru...
متن کاملOptimized Treatment and Heart Rate Reduction in Chronic Heart Failure
BACKGROUND Heart failure (HF) is a syndrome that leads to poor outcome in advanced forms. The neurohormonal blockade modifies this natural history; however, it is often suboptimal. OBJECTIVE The aim of this study is to assess at what percentage cardiologists used to treating HF can prescribe target doses of drugs of proven efficacy. METHODS A total of 104 outpatients with systolic dysfuncti...
متن کاملBenefit of Heart Rate Reduction in Heart Failure
Epidemiological studies have suggested that life expectancy is inversely related to resting heart rate and that the risks of development of heart failure and sudden cardiac death strongly increase with higher resting heart rates [1]. After myocardial infarction, the reduction in mortality with β-blocker treatment was correlated with the extent of heart rate reduction, and in patients with heart...
متن کاملIs heart rate reduction more important than target dose in chronic heart failure therapy with a beta-blocker?
Beta-adrenoceptor blocking agents (beta-blockers) are now well established as cornerstone therapy in patients with systolic chronic heart failure (CHF). Clinical data have overwhelmingly proven the beneficial effects of beta-blocker therapy in terms of improving patient prognosis, decreasing requirements for hospitalization, and postponing disease progression. However, it remains unclear what t...
متن کاملDecreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate.
A decrease in maximal exercise heart rate (HR(max)) is a key contributor to reductions in aerobic exercise capacity with aging. However, the mechanisms involved are incompletely understood. We sought to gain insight into the respective roles of intrinsic heart rate (HR(int)) and chronotropic beta-adrenergic responsiveness in the reductions in HR(max) with aging in healthy adults. HR(max) (Balke...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2009
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2008.12.074